新一代测序(NGS)为鉴定冠状病毒株和其他病原体提供了一种高效且无偏好的方法,技术本身摆脱了研究者自身对病原学知识的局限 1。对于快速传播的SARS-CoV-2冠状病毒的新型变异(如B.1.1.7株系[英国]和B1.351株系[南非]的担忧日益增加,凸显了用更多测序快速检测突变、防止新病毒株传播的需求。在疫情爆发初期,研究人员使用测序技术鉴定出了导致COVID-19的新型冠状病毒(SARS-CoV-2)2。NGS还可为公共卫生人员、疫苗和药物开发商以及研究人员提供关键证据,帮助实验室:
检测SARS-COV-2和诊断COVID-19 | 检测和监测呼吸道感染 | 检测新的病毒 | |
---|---|---|---|
检测需求 | 扩增子 Illumina COVIDSeq检测 (RUO) COVIDSeq Assay |
靶向富集 | 宏基因组学 |
检测速度 | |||
可扩展且经济高效 | |||
新病原体的鉴定 | |||
追踪传播 | |||
不受突变变化的影响 | |||
鉴定联合感染和复杂疾病 | |||
检测抗菌素耐药性 |
充分满足实验室的检测需求
部分满足实验室的检测需求
对给定样本中的所有生物体进行全面测序,鉴定冠状病毒等新型病原体。这种NGS方法有助于加速疫情调查,并支持新实验室检测方法的开发。
检测并鉴定呼吸道病原体和抗菌素耐药性。对致病性呼吸道生物体的通用性检测和抗菌素耐药性标志物可以帮助研究人员检测和监测SARS-CoV-2等呼吸道感染,并优化感染控制策略。
通过识别病原体基因组的特定区域来检测SARS-CoV-2的存在。该方法会使用PCR扩增子的超深度测序来分析目标基因组区域。
MiniSeq Rapid reagents reduce sequencing run times to < 5 hours, allowing fast detection of coronaviruses and other respiratory viruses.
阅读应用说明合作旨在扩展NGS在临床传染性疾病检测中的应用。在COVID-19大流行期间,两家公司已经加快了合作的进程,以此来为全球开展NGS的客户提供更好的支持,帮助他们进行监测。
阅读文章A Utah Public Health Lab director discusses how they've expanded their NGS operations in an effort to zero in on SARS-CoV-2 outbreak clusters and establish an infrastructure for future pandemics.
Read ArticleIn a groundbreaking initiative, public health labs use Illumina technology to sequence the viral genomes of all positive COVID-19 tests in Australia and track COVID-19 across the country, rather than state by state.
Read ArticleA collaborative environment leveraging BaseSpace Correlation Engine helps COVID-19 researchers validate hypotheses around important pathways, biomarkers, and potential drug candidate leads.
Read ArticleHow Aegis Sciences moved with the mutations, expanded capacity, and became one of the largest COVID sequencing operations in the world.
Read ArticleIn keeping with recommendations from the United States CDC and World Health Organization, Illumina recommends this procedure for decontaminating NGS instruments suspected or known to have come in contact with the novel coronavirus SARS-CoV-2 (2019-nCoV).
Read BulletinUse of ammonia-based cleaners and sanitizing products (frequently utilized to clean labs during the COVID-19 pandemic) in proximity to sequencing run setup can result in decreased sequencing run performance metrics. View tips on how to avoid these issues.
Read Bulletin使用多种样本快速制备文库,以无可匹敌的研究灵活性研究编码和非编码转录组。
独立的Illumina Ribo-Zero Plus Kit能去除人、小鼠、大鼠和细菌样本中的核糖体RNA。
能助您探索一系列现有及新兴应用,突破效率,突破极限的开创性台式测序仪。