Infinium MethylationEPIC Kit

Robust methylation profiling microarray with unparalleled coverage of CpG islands, genes, and enhancers. Use for epigenome-wide association studies. Read More...
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Infinium MethylationEPIC BeadChip Kit (16 samples)

WG-317-1001

Infinium MethylationEPIC BeadChip Kit (32 samples)

WG-317-1002

Infinium MethylationEPIC BeadChip Kit (96 samples)

WG-317-1003

Product Highlights

With the Infinium MethylationEPIC BeadChip Kit, researchers can interrogate over 850,000 methylation sites quantitatively across the genome at single-nucleotide resolution. Multiple samples, including FFPE, can be analyzed in parallel to deliver high-throughput power while minimizing the cost per sample.

Infinium HD array technology enables content selection independent of bias-associated limitations often associated with methylated DNA capture methods. The result is a pan-enhancer and coding region view of the methylome that can be used for epigenome-wide association studies on a variety of human tissues.

Comprehensive Genome-Wide Coverage

This kit includes the following content categories requested by methylation experts:

  • CpG sites outside of CpG islands
  • Non-CpG methylated sites identified in human stem cells (CHH sites)
  • Differentially methylated sites identified in tumor versus normal
  • FANTOM5 enhancers
  • ENCODE open chromatin and enhancers
  • DNase hypersensitive sites
  • miRNA promoter regions
  • > 90% of content contained on the Illumina HumanMethylation450K BeadChip
Integrated Analysis Software

MethylationEPIC data analysis is supported by the GenomeStudio Methylation Module. GenomeStudio software enables researchers to effortlessly perform differential methylation analysis for small-scale studies. It features advanced visualization tools that enable researchers to view vast amounts of data in a single graph, such as heat maps, scatter plots, and line plots.

These tools and the GenomeStudio Genome Browser display valuable information such as chromosomal coordinates, percent GC, location in a CpG Island, and methylation β values.

For large-scale studies, there are many free analysis packages that work in the software framework R for normalization, and differential analysis of methylation data. Instructional videos explain the use of these data analysis packages.

Frequently Purchased Together

规格

产品比较

Infinium MethylationEPIC Kit TruSeq Methyl Capture EPIC Library Prep Kit
变异种类 差异甲基化胞嘧啶 差异甲基化胞嘧啶
技术 微阵列芯片 测序
核酸类型 DNA DNA
物种类别 人类 人类
系统兼容性 iScan NextSeq 500 , HiSeq 2500 , NextSeq 550 , HiSeq 3000 , HiSeq 4000

Method-Specific Workflow Example

 

Customer Stories

癌症转移之谜

研究人员使用HumanMethylation450 BeadChip芯片和HiSeq系统研究癌症转移的表观遗传学。

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表观遗传学研究揭示了肥胖所引起的甲基化特征

研究人员采用Infinium HumanMethylation450 BeadChip芯片鉴定对高BMI的负下游效应有重要影响的细胞信号通路中断。

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