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The Infinium Global Screening Array-24 BeadChip combines multi-ethnic genome-wide content, curated clinical research variants, and quality control (QC) markers for precision medicine research.
The genome-wide content was selected for high imputation accuracy at minor allele frequencies of >1% across all 26 1000 Genomes Project populations. The clinical research content includes variants with established disease associations, relevant pharmacogenomics markers, and curated exonic content based on ClinVar, NHGRI, PharmGKB, and ExAC databases. QC content enables sample identification and tracking for large-scale genomics and screening applications.
With over 15 million samples worth of BeadChips sold, the Global Screening Array's global adoption provides a network of human disease researchers, healthcare networks, consumer genomics companies, and genomic service providers to help power discovery.
The array supports genotyping and CNV calling for sample types including saliva, blood, and buccal swabs. The format allows processing of hundreds to thousands of samples per week with a 3-day workflow for population-scale studies.
The array provides a genomic tool for clinical research applications including disease risk profiling studies, pharmacogenomics research, wellness characterization, and complex disease discovery.
Version 3 of the Global Screening Array leverages the most up to date and relevant clinical research screening markers derived from ClinVar, CPIC, and PharmGKB.
As leading databases such as ClinVar continue to rapidly add new variants, Illumina is dedicated to ensuring the variants interrogated on the GSA remain updated and relevant. The launch of the Infinium GSA-24 v3.0 BeadChip includes an update of key variants found in ACMG 59 genes. A growing number of precision medicine research initiatives around the world are leveraging these variants to screen populations for the following applications:
Infinium Global Screening Array-24 Kit | Infinium Multi-Ethnic Global-8 Kit (Discontinued) | Infinium Omni2.5-8 Kit | |
---|---|---|---|
技术 | 芯片 | 芯片 | 芯片 |
标记物数量 | 固定标记物:约654,027 定制标记物扩展容量可达 50,000 |
固定标记物: 1,779,819 定制标记物扩展容量:多达245,000个 |
固定标记物:约2,381,000, 定制标记物扩展容量:无 |
样本数量 | 每张芯片24个样本 | 每张芯片8个样本 | 每张芯片8个样本 |
样本通量 | 每台iScan系统可处理约5760个样本/周(通量和扫描时间可能因实验室和系统配置而异。) | 每台iScan系统最多可处理约1728个样本/周(通量和扫描时间可能因实验室和系统配置而异。) | 每台iScan系统可处理约1728个样本/周(最大通量和扫描时间可能因实验室和系统配置而异。) |
核酸类型 | DNA | DNA | DNA |
物种类别 | 人类 | 人类 | 人类 |
说明 | 经济实用的新一代基因分型芯片,通过结合高度优化的多种族全基因组内容、精选的临床研究变异和QC标记物支持群体规模的遗传学、转化研究、变异筛查研究和精准医疗研究。 | 这款多种族芯片包含来自多个资源渠道的内容,让研究人员能够在5个最常作为研究对象的超群体中检测常见和罕见变异,以推断大量亚群中可能存在的变异。 | 8样本芯片具有高通量和优化的标签SNP内容,全面支持拷贝数变异应用,旨在提供高度可定制、信息量大的芯片用于研究不同的世界人口群体。 |
Fast Infinium array analysis and broad genome coverage support personal genetic testing services and database development.
Read InterivewMyDNA recently began partnering with Illumina customers using the Global Screening Array and Asian Screening Array in their genetic test offerings.
Read InterviewResearchers perform large GWAS studies with the Global Screening Array to identify disease-associated DNA risk loci and develop PRSs for clinical validation.
Read InterviewThe Global Screening Array and iScan System are helping Mapmygenome bring consumer genomics to a rapidly growing Indian population.
Read ArticleData Sheet | PDF | 5 versions
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