Chromatin immunoprecipitation sequencing (ChIP-Seq or ChIP-exo ) or high-throughput chromatin immunoprecipitation (HT-ChIP ), is a well-established method to map specific protein-binding sites. In this method, DNA-protein complexes are crosslinked in vivo. Samples are then fragmented and treated with an exonuclease to trim unbound oligonucleotides. Protein-specific antibodies are used to immunoprecipitate the DNA-protein complex. The DNA is extracted and sequenced, giving high-resolution sequences of the protein-binding sites.