开展NIPT的有利时机
非侵入性产前检测（NIPT），又称游离DNA（cfDNA）筛查，是一种产前非整倍性筛查检测。借助孕妇外周血，NIPT最早可以在孕10周采用非侵入性方式筛查胎儿染色体非整倍体。2
非侵入性
NIPT和抽血一样安全、简单。2
准确
了解产前遗传健康风险，对21三体、18三体和13三体的筛查准确率高达99%以上。1
早期
NIPT可在孕10周（最早）至足月进行。2
检测侵入性更小意味着母婴风险更小
与传统的产前血清筛查相比，采用和实施NIPT具有许多优势，可以为您的妊娠管理提供信息。4-8
1000例妊娠中，为了检测21、18、13三体而进行的不必要的侵入性手术的数量
NIPT
假阳性率：0.13%7
~1
不必要的侵入性手术
vs
传统筛查
假阳性率：4%9
40
不必要的侵入性手术
所示的数据来自于假设的1000名孕妇，她们在每次检测中都会得到假阳性结果，因此需要进行确认性诊断检测。
了解同行如何将NIPT纳入实践
这些页面面向医疗保健专业人士。此内容中引用的某些解决方案可能在特定地区不可用或未获批准。
References
- Data on file, Illumina, Inc. 2019.
- American College of Obstetricians and Gynecologists. Screening for fetal aneuploidy. Practice Bulletin No. 163. Am J Obstet Gynecol. 2016;127(5):e123-e137.
- Pertile MD, Halks-Miller M, Flowers N, et al. Rare autosomal trisomies, revealed by maternal plasma DNA sequencing, suggest increased risk of feto-placental disease. Sci Transl Med. 2017;9(405):1-11.
- Platt LD, Janicki MB, Prosen T, et al. Impact of noninvasive prenatal testing in regionally dispersed medical centers in the United States. Am J Obstet Gynecol. 2014;211(4):368.e1-368.e7.
- Larion S, Warsof SL, Romary L, Mlynarczyk M, Peleg D, Abuhamad AZ. Association of combined first-trimester screen and noninvasive prenatal testing on diagnostic procedures. Obstet Gynecol. 2014;123(6):1303-1310.
- Bianchi DW, Parker RL, Wentworth J, et al; for CARE Study Group. DNA sequencing versus standard prenatal aneuploidy screening. N Engl J Med. 2014;370(9):799-808.
- Gil MM, Accurti V, Santacruz B, Plana MN, Nicolaides KH. Analysis of cell-free DNA in maternal blood in screening for aneuploidies: updated meta-analysis. Ultrasound Obstet Gynecol. 2017;50:302-314.
- Chudova DI, Sehnert AJ, Bianchi DW. Copy-number variation and false positive prenatal screening results. N Engl J Med. 2016;375(1):97-98.
- Santorum M, Wright D, Syngelaki A, Karagioti N, Nicolaides KH. Accuracy of first-trimester combined test in screening for trisomies 21, 18 and 13. Ultrasound Obstet Gynecol. 2017;49(6):714-720.