Benefits of DNA-Protein Interaction Studies
Analysis of DNA-protein interactions provides researchers with insight into regulation events that are critical for many biological processes and disease states. This epigenetic information is complementary to DNA sequencing, genotyping, gene expression, and other forms of genomic analysis.
Analyzing DNA-Protein Interactions with Sequencing
By combining chromatin immunoprecipitation (ChIP) and massively parallel sequencing, ChIP-Seq accurately surveys interactions between protein, DNA, and RNA, enabling the interpretation of regulation events central to many biological processes and disease states. Use ChIP-Seq to identify transcription factor binding sites, track histone modifications across the genome, and narrow in on chromatin structure and function.
Related Solutions
Detect DNA-Protein Interactions in Tumors
Altered transcription factor binding is a common epigenetic pattern in cancer. ChIP-Seq experiments provide researchers with a complete snapshot of DNA regions associated with a protein of interest. Learn more about cancer epigenetics.
Gene Expression in Common Disease
Gene expression and regulation analysis studies can reveal insights into the biological impact of genomic alterations observed in complex diseases. Learn more about gene expression profiling and regulation.
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Additional Resources
Sequencing Methods Review
A collection of NGS sample prep protocols, including ChIP-Seq, compiled from peer-reviewed publications.
Epigenome Roadmap
A collection of research papers that systematically characterize epigenomic landscapes in primary human tissues and cells.
Epigenome Blueprint
A consortium generating 100 reference epigenomes to understand gene activation and repression in healthy and diseased human cells.
ENCODE
The ENCODE Consortium built a comprehensive parts list of relevant proteins on the genome and set standards for generating and analyzing ChIP-Seq data.