Microbes that influence cytokine release and inflammation can exert either a positive or negative effect on tumor growth, or the ability of the immune system to suppress tumor growth.
NGS allows profiling of microbial communities in different contexts, which is critical for identifying species or conditions that may be targeted for developing new therapeutic approaches to cancer.
The ability of NGS to analyze complex microbial communities may help to uncover new mechanisms of host–microbe interactions that promote cancer or promote drug efficacy.
The throughput and cost savings of NGS have fueled metagenomics studies capable of surveying the genomes of entire microbial communities.
A DNA sequencing method that enables comprehensive sampling of all genes in all organisms in complex microbiome samples.
A 16S ribosomal RNA gene sequencing method used to identify and compare bacteria present within a given sample.
Analysis of all RNAs encoded by a group of microorganisms within a complex sample.
Sequencing technologies are enabling a deeper analysis of the gut's microbiome. Researchers can now explore what our microbial inhabitants are doing and how they contribute to, or protect from, diseases such as cancer and autoimmune disorders.Read Article
Dr. Samuel Minot from the Fred Hutchinson Cancer Research Center discusses a novel gene-level bioinformatics approach for identifying microbial species and strains associated with human diseases such as cancer, from metagenomic sequencing datasets.View Webinar
Unify single-cell gene expression and ATAC-Seq to help reveal cellular mechanisms driving gene regulation.Read Tech Note
Learn how to incorporate protein detection into bulk RNA-Seq and develop a workflow for BEN-Seq, providing a holistic approach to cell analysis.Read App Note