African American Admixture Panel

System:	iScan, BeadArray Reader, HiScanSQ
Technology:	BeadArray
Assay:	GoldenGate Genotyping Assay
Applications:	Focused Genotyping
Species:	Human
Contents:	Contains one OPA for 1,509 SNP loci

The Illumina African American Admixture Panel facilitates detection of susceptibility loci of genetic variants that differ in frequency between ancestral African and European populations. This panel enables a highly-efficient scan for genetic disease risk factors across the entire genome, using a minimum number of markers. The Panel contains 1,509 SNPs for admixture mapping studies in African American populations.

Relatively little recombination between African- and European-derived chromosomes has yielded segments of either ancestry that are typically tens of megabases long. By targeting markers to these large, single-ancestry derived, chromosomal segments, only relevant variance in the admixed population is interrogated.

Samples from disease cases can be genotyped and compared to find regions of the genome where the proportion of African ancestry is different from the genome-wide average. Regions with African ancestry deviating from average are likely to contain genetic variants associated with disease.

By specifically targeting variation between European and African chromosomes relatively few markers provide the same power as hundreds-fold more randomly chosen SNPs. Consequently, many more samples can be analyzed with an intelligently targeted genotyping panel at much lower cost.

• Diseases where African American admixture mapping is anticipated to be effective include prostate cancer, Type-II diabetes, autoimmune diseases (e.g. multiple sclerosis), hypertension, asthma, and obesity

• The African American Admixture Panel utilizes Illumina's GoldenGate Genotyping Assay